منابع مشابه
Transcription factor binding at enhancers: shaping a genomic regulatory landscape in flux
The mammalian genome is packed tightly in the nucleus of the cell. This packing is primarily facilitated by histone proteins and results in an ordered organization of the genome in chromosome territories that can be roughly divided in heterochromatic and euchromatic domains. On top of this organization several distinct gene regulatory elements on the same chromosome or other chromosomes are tho...
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κ-casein is a glycosilated protein in mammalian milk that plays an essential role in the milk micelles. Control of κ-casein expression reflects this essential role, although an understanding of the mechanisms involved lags behind that of the other milk protein genes. Transcriptional regulation, a first mechanism for controlling the development of organisms, is carried out by transcription facto...
متن کاملMapping of Transcription Factor Binding Region of Kappa Casein (CSN3) Gene in Iranian Bacterianus and Dromedaries Camels
κ-casein is a glycosilated protein in mammalian milk that plays an essential role in the milk micelles. Control of κ-casein expression reflects this essential role, although an understanding of the mechanisms involved lags behind that of the other milk protein genes. Transcriptional regulation, a first mechanism for controlling the development of organisms, is carried out by transcription facto...
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Current high-throughput experiments already generate enough data for retrieving the DNA sequence-dependent binding affinities of transcription factors (TF) and other chromosomal proteins throughout the complete genome. However, the reverse task of calculating binding maps in a chromatin context for a given set of concentrations and TF affinities appears to be even more challenging and computati...
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A random forest classifier for transcription factor binding properties. (Fig. 1). O ne of the central questions in molecular genetics regards the mechanisms of transcriptional regulation , particularly how transcription factors (TFs) regulate expression of target genes with specific TF binding sites (TFBSs). Identifying TFBSs would permit a more comprehensive and quantitative mapping of the reg...
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ژورنال
عنوان ژورنال: Nature Reviews Genetics
سال: 2015
ISSN: 1471-0056,1471-0064
DOI: 10.1038/nrg3944